Dozor A.J., Krishnan S.

The Study of Soy Supplementation in Asthma

This study is to test the hypothesis that patients with symptomatic asthma have improved lung function when treated with a soy isoflavone dietary supplement.

Dozor A.J., Krishnan S.

Relationship between atmospheric and weather conditions and pulmonary function in children with asthma.

This is a large epidemiological study examining the relationship between temperature, humidity and barometric pressure and measurements of lung function obtained in children with asthma.

Valsamis C., Krishnan S., Dozor A.J.

Environmental Tobacco Smoke and pulmonary function tests in young children with asthma: Impulse Oscillometry and Airway Reactivity.

Evidence is mounting that the toxic effects of exposure to second hand smoke are greatest in young children when their lungs are growing. Our Pediatric Pulmonary Function Laboratory can now make exquisitely sensitive measurements of lung function in toddlers and preschool children. (Previously these kinds of measurements could only be done in children around six years of age or older.) This study is designed to examine the effects of exposure to environmental tobacco smoke on those measurements.

DeLaRiva-Velasco E., Krishnan S., Dozor A.J.

Airway Inflammation and Environmental Tobacco Smoke: Cytokines in Exhaled Breath Condensate.

This is a basic laboratory study designed to help unravel the biochemical pathways that link second hand smoke to lung disease in children. In this study, we are using a very new and potentially very exciting technique. We are collecting the moisture in the breath of children with asthma and testing that liquid for signs of inflammation.

Dozor A.J. and Balazy M.

Nitrooxidative Stress: The effects of Environmental Tobacco Smoke on airway inflammation and trans-arachidonic acid mediators in asthma.

This study is a collaborative effort of the staff of the Children's Environmental Health Center and the basic scientists at New York Medical College . The purpose of this study is to better understand exactly why exposure to second hand smoke is so bad for children with asthma.

Dozor A.J. and Krishnan S.

The relationship between Exposure to Environmental Tobacco Smoke and Gastroesophageal Reflux in children with Asthma (Substudy of SARCA: The Study of Acid Reflux in Children with Asthma, a multicenter placebo-controlled trial in children with asthma.)

Our Pediatric Pulmonology Division is an American Lung Association Asthma Clinical Research Center. As such we participate in large nationwide clinical studies of asthma. In this particular study, we are examining the relationship between two common problems: asthma and gastroesophageal reflux. This substudy from the staff of the Children's Environmental Health Center is designed to further analyze this relationship in terms of the role of exposure to second hand smoke, which is known to worsen both of these common clinical problems. The interaction between these three problems is the focus of our research.